Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination
نویسندگان
چکیده
منابع مشابه
Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination.
Recent evidence suggests that astrocytes play an important role in regulating de- and remyelination in multiple sclerosis. The role of astrocytes is controversial, and both beneficial as well as detrimental effects are being discussed. We performed loss-of-function studies based on astrocyte depletion in a cuprizone-induced rodent model of demyelination. This led to strong astrogliosis accompan...
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ژورنال
عنوان ژورنال: Brain
سال: 2012
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/aws262